Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and Digits

Printed in color through the courtesy of Ciba Pharmaceutical Products, Inc., Summit, New Jersey.IN 1944, a brief report was made by one of us1 regarding the association, in 2 patients, of a distinctive type of melanin pigmentation of the oral mucosa, lips and digits with intestinal polyposis.Since then 10 cases, including the 2 referred to above, have been collected from five different hospitals and are reported here in detail along with a review of pertinent literature and a discussion of the significance of this syndrome.Case ReportsCase 1. A 14-year-old American schoolgirl entered the Fifth Medical Service . . .