Heterocyclic Scaffold Modification of Chalcones: Piperidinyl and Morpholinyl Triazene Derivatives as Potent Blood Stage Antimalarials With SAR and Docking Insights

Puntos clave

• This research aims to enhance antiplasmodial activity through the modification of heterocyclic scaffolds in chalcones.
• Developed piperidinyl and morpholinyl triazene derivatives of chalcones.
• Performed molecular docking studies to evaluate interactions with Plasmodium falciparum-dihydrofolate reductase.
• Assessed hemolytic activity of the compounds to ensure safety.
• All tested compounds displayed non-hemolytic properties.
• Molecular docking revealed favorable interactions with the target enzyme.
• Heterocyclic scaffold modification significantly increased antiplasmodial activity.