Cost-Effectiveness Analysis of a Procalcitonin-Guided Decision Algorithm for Antibiotic Stewardship Using Real-World U.S. Hospital Data

and ABR infections. The PCT-guided health care resulted in cost savings of 25, 611 (49% reduction from standard care) for sepsis and 3630 (23% reduction) for LRTI, on average per patient. In conclusion, the PCT decision algorithm for ABS in sepsis and LRTI might offer cost savings in comparison with standard care in a U. S. hospital context. To the best of our knowledge, this is the first health economic analysis on PCT implementation using U. S. real-world data. We suggest that future CEA studies in other U. S. and worldwide settings are warranted in the current age when PCT and other decision algorithms are increasingly deployed in precision therapeutics and evidence-based medicine.