Plasma-Cell Myeloma

THE purpose of this article is primarily to review the more recent acquisitions to the knowledge and understanding of the pathophysiology of the plasma-cell dyscrasias. Several comprehensive studies of the clinical, radiographic, pathological and biochemical features of multiple myeloma have been published in the past thirty years.1 2 3 4 5 6 7 8 9 10 11 12 13 Major emphasis in this presentation, however, will be given to specific topics pertaining to plasma-cell neoplasia in which recent progress has been made.The "typical" case of multiple myeloma, if, indeed, such an entity exists, must now be considered as representing just one of several clinical patterns that may arise from a primary . . .