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September 27, 2021Journal of Vascular Research6 citations

The Impact of Fitness Status on Vascular and Baroreceptor Function in Healthy Women and Men

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GLGarth R. LesterFAFrancesca S. AbiusiMBMichael E. Bodner

Key Result

Endurance-trained adults had significantly greater large arterial compliance (21.4) compared to normally active (16.9; p=0.002) and inactive adults (14.7; p=0.028).

Study Design

Type

Cross-Sectional (n=80)

Structured PICO

Does endurance training or normal physical activity improve vascular and baroreceptor function compared to inactivity in healthy adults?

P
Population
80 healthy adults, mean age 38.5 ± 9.7 years, 44% female
I
Intervention
Endurance-trained (ET, n=29) or normally active (NA, n=27) lifestyle
C
Comparator
Inactive (IN, n=24) lifestyle
O
Outcome
Cardiovascular markers including hemodynamics, large arterial compliance (LAC), small arterial compliance (SAC), carotid-femoral pulse wave velocity (PWV), and spontaneous baroreceptor sensitivity (BRS)surrogate

High-volume endurance training increases large arterial compliance, while lower volumes of physical activity are sufficient to improve overall vascular health compared to inactivity.

Main Result

Absolute Event Rate: 21.4% vs 14.7%

p-value: p=0.028

Abstract

BACKGROUND: Chronic endurance exercise training elicits desirable physiological adaptations in the cardiovascular system. The volume of exercise training required to generate healthy adaptations is unclear. This study assessed the effects of differing exercise training levels on arterial stiffness, compliance, and autonomic function. METHODS: Eighty healthy adults (38.5 ± 9.7 years; 44% female) defined as endurance-trained (ET, n = 29), normally active (NA, n = 27), or inactive (IN, n = 24) participated. Cardiovascular markers, including hemodynamics, large arterial compliance and small arterial compliance (LAC and SAC), carotid-femoral pulse wave velocity (PWV), and spontaneous baroreceptor sensitivity (BRS) were assessed. RESULTS: ET showed significantly greater LAC values (21.4 ± 6.5) than NA (16.9 ± 2.5; p = 0.002) and IN (14.7 ± 3.2 mL × mm Hg × 10; p = 0.028). Values for SAC and BRS were significantly higher in ET than IN (p < 0.001 and p = 0.028, respectively), but not NA. Compared to IN, PWV values for ET and NA were significantly lower (p < 0.003). After adjusting for covariates (age, sex, and SBP), significant associations with cardiovascular fitness status were noted for all markers but BRS. CONCLUSION: Endurance exercise increases LAC likely due to high-volume training; however, lower volumes of physical activity may be sufficient to positively benefit vascular health overall.

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Cite This Study

Lester et al. (2021) conducted a cross-sectional in Healthy adults (n=80). Endurance training vs. Normally active or inactive status was evaluated on Large arterial compliance (LAC) (p=0.028). Endurance-trained adults had significantly greater large arterial compliance (21.4) compared to normally active (16.9; p=0.002) and inactive adults (14.7; p=0.028).

synapsesocial.com/papers/6a07601a041f8ce9c3582a1bhttps://doi.org/10.1159/000518985
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