Among older adults ≥74 years of age, greater aortic stiffening is associated with biomarker evidence of neuroinflammation, tau phosphorylation, synaptic dysfunction, and neurodegeneration (P<0.001).
Observational
Is increased aortic stiffening associated with greater CSF biomarker evidence of neuroinflammation, synaptic dysfunction, and neurodegeneration in older adults?
Greater aortic stiffness in older adults is associated with CSF biomarkers of neuroinflammation and neurodegeneration, suggesting a link between central arterial stiffening and cerebral microcirculatory damage.
p-value: p=< 0.001
OBJECTIVES: To test the hypothesis that increased aortic stiffening is associated with greater CSF evidence of core Alzheimer disease pathology (β-amyloid Aβ, phosphorylated tau p-tau), neurodegeneration (total tau t-tau), synaptic dysfunction (neurogranin), neuroaxonal injury (neurofilament light NFL), and neuroinflammation (YKL-40, soluble triggering receptor expressed on myeloid cells 2 sTREM2), we analyzed pulse wave velocity (PWV) data and CSF data among older adults. METHODS: ε4, and hypertension on each biomarker. RESULTS: < 0.001). CONCLUSIONS: Among our oldest participants, ≥74 years of age, greater aortic stiffening is associated with in vivo biomarker evidence of neuroinflammation, tau phosphorylation, synaptic dysfunction, and neurodegeneration, but not amyloidosis. Central arterial stiffening may lead to cumulative cerebral microcirculatory damage and reduced blood flow delivery to tissue, resulting in neuroinflammation and neurodegeneration in more advanced age.
Moore et al. (2021) conducted an observational in Alzheimer disease pathology. Aortic stiffness (Pulse wave velocity) was evaluated on CSF evidence of core Alzheimer disease pathology, neurodegeneration, synaptic dysfunction, neuroaxonal injury, and neuroinflammation (p=< 0.001). Among older adults ≥74 years of age, greater aortic stiffening is associated with biomarker evidence of neuroinflammation, tau phosphorylation, synaptic dysfunction, and neurodegeneration (P<0.001).