A post-discharge physical rehabilitation intervention significantly improved quality of life at 3 months in older patients hospitalized for acute decompensated heart failure (P<0.001).
RCT (n=349)
Does a multi-domain physical rehabilitation intervention improve quality of life in older patients admitted for acute decompensated heart failure?
A post-discharge physical rehabilitation intervention significantly improves quality of life at 3 months in older patients hospitalized for acute decompensated heart failure, mediated by improvements in physical performance.
valor p: p=<0.001
BACKGROUND: As patients with heart failure experience worsening of their condition, including acute decompensated heart failure, quality of life deteriorates. However, the trajectory of quality of life changes and their determinants in the context of the Rehabilitation Therapy in Older Acute Heart Failure Patients trial physical rehabilitation intervention are unknown. METHODS: Patients ≥60 years old admitted for acute decompensated heart failure (n=349) were randomized to either attention control or intervention. Quality of life outcomes (Kansas City Cardiomyopathy Questionnaire; 12-Item Short-Form Health Survey) were measured at baseline (inpatient), 1 month, and 3 months. Intervention effects were assessed using linear mixed effects regression, including covariates to model the main effects of the intervention and timing of outcome assessments. Mediation analysis determined if changes in Kansas City Cardiomyopathy Questionnaire were due to improvement in physical function (short physical performance battery, 6-minute walk distance). RESULTS: <0.001). CONCLUSIONS: In older patients hospitalized for acute decompensated heart failure, quality of life improves in the first month after discharge. The quality of life benefit of a post-discharge physical rehabilitation intervention is detected early with large significant improvements at 3 months achieved primarily through improvement in short physical performance battery. REGISTRATION: URL: https://clinicaltrials.gov; Unique identifier: NCT02196038.
Whellan et al. (Tue,) conducted a rct in Acute decompensated heart failure (n=349). Physical rehabilitation intervention vs. Attention control was evaluated on Quality of life outcomes (Kansas City Cardiomyopathy Questionnaire; 12-Item Short-Form Health Survey) (p=<0.001). A post-discharge physical rehabilitation intervention significantly improved quality of life at 3 months in older patients hospitalized for acute decompensated heart failure (P<0.001).