Despite numerous reports of genetic associations with performance-related phenotypes, progress in characterizing the genetic contribution to elite performance remains limited due to small sample sizes and reliance on candidate gene approaches.
Current sports genetics knowledge relies heavily on underpowered candidate gene studies, highlighting the need for large-scale, collaborative genome-wide association studies to identify true genetic contributors to elite performance.
Numerous reports of genetic associations with performance-related phenotypes have been published over the past three decades but there has been limited progress in discovering and characterising the genetic contribution to elite/world-class performance, mainly owing to few coordinated research efforts involving major funding initiatives/consortia and the use primarily of the candidate gene analysis approach. It is timely that exercise genomics research has moved into a new era utilising well-phenotyped, large cohorts and genome-wide technologies--approaches that have begun to elucidate the genetic basis of other complex traits/diseases. This review summarises the most recent and significant findings from sports genetics and explores future trends and possibilities.
Pitsiladis et al. (Tue,) conducted a review in Elite sporting performance. Genomic analysis was evaluated. Despite numerous reports of genetic associations with performance-related phenotypes, progress in characterizing the genetic contribution to elite performance remains limited due to small sample sizes and reliance on candidate gene approaches.
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