Enzymatic C-Acylation Enables Diversification of Tetramate Antibiotic Scaffolds

Puntos clave

• The research aims to explore an enzymatic method for diversifying tetramate antibiotic scaffolds.
• Utilized an enzymatic C-acylation approach to modify tetramate structures.
• Assessed the potential of the platform in expanding the chemical diversity of metabolites.
• Demonstrated successful diversification of tetramate scaffolds via enzymatic reaction.
• Highlighted the increase in chemical space of tetramate metabolites.