A two-year increase in TyG-WHtR exceeding 0.400 was associated with a 30% higher risk of MACE (HR 1.30; 95% CI 1.00-1.69) compared to a lower increase.
Cohort (n=3,466)
No
Does a higher two-year increase in the triglyceride glucose‒waist height ratio (TyG‒WHtR) index increase the risk of major adverse cardiovascular events in a community-based population without prior stroke or MI?
A short-term increase in the TyG-WHtR index, reflecting metabolic worsening, is associated with a higher risk of future MACE, an effect partially mediated by concurrent increases in mean arterial pressure.
Estimación del efecto: HR 1.30 (95% CI 1.00-1.69)
It remains unclear whether a fixed-period increase in the triglyceride glucose‒waist height ratio (TyG‒WHtR) index, an indicator of short-term metabolic worsening, is associated with future cardiovascular disease (CVD) risk. To investigate this, we conducted a prospective cohort study in a Beijing community-based population in China, enrolling participants without a history of stroke or myocardial infarction (MI). The primary outcome was major adverse cardiovascular events (MACEs), defined as a composite of MI, stroke, and cardiovascular death. We employed Cox proportional hazards models with landmark analysis to evaluate the association. Among 3466 individuals followed for a median of 7.52 years since 2014, 270 MACE events occurred. Our analysis suggested a potential threshold effect, with CVD risk increasing more markedly when the TyG-WHtR increase exceeded approximately 0.400. Using this cutoff, individuals with a higher two-year increase in TyG-WHtR had a 30% higher risk of MACE (hazard ratio HR 1.30, 95% confidence interval CI 1.00-1.69) compared to those with lower increase. Landmark analysis revealed no significant association during the first 2 years; however, beyond this period, the association emerged, with an HR of 1.41 (95% CI 1.06-1.89). Further mediation analysis revealed that concurrent changes in mean arterial pressure (MAP) explained 30.4% of the association between changes in TyG-WHtR and MACEs. In conclusion, an increase in TyG-WHtR reflecting short-term metabolic worsening, is associated with an increased MACE risk, and this relationship appears to be partly mediated by changes in MAP.
Luo et al. (Fri,) conducted a cohort in Cardiovascular disease risk (n=3,466). Higher two-year increase in TyG-WHtR (>0.400) vs. Lower increase in TyG-WHtR was evaluated on Major adverse cardiovascular events (MACEs), defined as a composite of MI, stroke, and cardiovascular death (HR 1.30, 95% CI 1.00-1.69). A two-year increase in TyG-WHtR exceeding 0.400 was associated with a 30% higher risk of MACE (HR 1.30; 95% CI 1.00-1.69) compared to a lower increase.