Non-invasive myocardial work assessment revealed significantly lower global and segmental work indices in T2DM patients with and without hypertension compared to normal controls (p < 0.05).
Observational (n=190)
Does myocardial work assessment detect subclinical left ventricular myocardial systolic dysfunction in T2DM patients with and without hypertension?
Myocardial work assessment via echocardiography can non-invasively detect subclinical global and segmental left ventricular systolic dysfunction in patients with type 2 diabetes, which is further exacerbated by concurrent hypertension.
valor p: p=<0.05
OBJECTIVE: The research was aimed to evaluate the subclinical left ventricular (LV) myocardial systolic dysfunction in T2DM patients with or without hypertension (HT) by global and segmental myocardial work (MW). METHODS: A total of 120 T2DM patients (including 60 T2DM patients with HT) and 70 sex- and age- matched normal controls were included. The global and segmental variables of work index (WI), constrictive work (CW), waste work (WW), work efficiency (WE), and CW/WW were analysed by non-invasive pressure-strain loop. Receiver operating characteristic (ROC) analysis was performed for detection the subclinical LV systolic dysfunction in T2DM patients with and without HT. RESULTS: The global work index (GWI), global CW (GCW), global WE (GWE), and GCW/global WW (GWW) of T2DM and T2DM patients with HT were significantly lower than normal controls (p < 0.05). The WI, CW, WE, and CW/WW of the LV anterior wall in T2DM and T2DM patients with HT were significantly lower when compared with those of the normal controls (p < 0.05). ROC analysis showed that the value of area under the curve (AUC) in combined GWI, GCW, GWE, and GCW/GWW was significantly higher than the AUCs of the individual indices (p < 0.05). CONCLUSIONS: MW can non-invasively and accurately evaluate subclinical global and segmental LV myocardial systolic dysfunction in T2DM patients with and without HT. Regulating total cholesterol levels and controlling blood pressure in T2DM patients with and without HT might reduce the impairment of LV myocardial systolic function.
Li et al. (Fri,) conducted a observational in Type 2 diabetes mellitus with or without hypertension (n=190). Global and segmental myocardial work assessment vs. Normal controls was evaluated on Subclinical left ventricular myocardial systolic dysfunction assessed by global and segmental myocardial work indices (p=<0.05). Non-invasive myocardial work assessment revealed significantly lower global and segmental work indices in T2DM patients with and without hypertension compared to normal controls (p < 0.05).