March 30, 2015

Acyl Azolium Fluorides for Room Temperature Nucleophilic Aromatic Fluorination of Chloro- and Nitroarenes

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Resumen

The reaction of acid fluorides with N-heterocyclic carbenes (NHCs) produces anhydrous acyl azolium fluorides. With appropriate selection of acid fluoride and NHC, these salts can be used for the room temperature SNAr fluorination of a variety of aryl chlorides and nitroarenes.

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Ryan et al. (Mon,) studied this question.

synapsesocial.com/papers/6a08673c113ba5b476de236a https://doi.org/https://doi.org/10.1021/acs.orglett.5b00538

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