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June 22, 2022Frontiers in Oncology82 citationsOpen Access

ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism

HYHanxun YueFirst Hospital of Lanzhou University ZHZenan HuXi'an University of Science and Technology RHRui HuHebei Medical University

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Resumen

the maintenance of cancer stem cell properties, modification of metabolism, promotion of DNA repair. ALDH1A1 expression is regulated by several epigenetic processes. ALDH1A1 also acted as a tumor suppressor in certain cancers. The detoxification of ALDH1A1 often causes chemotherapy failure. Currently, ALDH1A1-targeted therapy is widely used in cancer treatment, but the mechanism by which ALDH1A1 regulates cancer development is not fully understood. This review will provide insight into the status of ALDH1A1 research and new viewpoint for cancer therapy.

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ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism | Synapse

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Yue et al. (Wed,) studied this question.

synapsesocial.com/papers/6a087bfd113ba5b476de360c https://doi.org/https://doi.org/10.3389/fonc.2022.918778