Why the study?
Although AF frequently coexists with HFpEF, few data are available evaluating AF-specific care patterns and post-discharge outcomes in patients hospitalized for HFpEF.
What are the AF-specific care patterns and post-discharge outcomes among patients hospitalized for HFmrEF or HFpEF, based on AF history?
Population
>400 000 participants hospitalized for HFmrEF or HFpEF in the Get With The Guidelines-Heart Failure Registry
Comparison
Patients with AF vs without AF history
Design
Registry-based cohort study
Key result
Comorbid atrial fibrillation in patients hospitalized for heart failure with mildly reduced or preserved ejection fraction was associated with a higher 12-month risk of all-cause mortality (35% vs 29%).
Authors
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Comorbid AF signals higher post-discharge mortality in HFmrEF/HFpEF; leaves open whether intensified anticoagulation or rhythm control improves outcomes.
Cohort (n=429,464)
Yes
What are the AF-specific care patterns and post-discharge outcomes among patients hospitalized for HFmrEF or HFpEF, based on AF history?
Absolute Event Rate: 35% vs 29%
p-value: p=<0.0001
In patients hospitalized with HFmrEF or HFpEF, comorbid AF is increasingly prevalent and associated with worse outcomes, yet the use of AF-specific therapies like anticoagulation and rhythm control remains modest.
Patel et al. (2022) conducted a cohort in Heart failure with mildly reduced and preserved ejection fraction (n=429,464). Atrial fibrillation vs. No history of atrial fibrillation was evaluated on 12-month all-cause mortality (p=<0.0001). Comorbid atrial fibrillation in patients hospitalized for heart failure with mildly reduced or preserved ejection fraction was associated with a higher 12-month risk of all-cause mortality (35% vs 29%).
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