Left atrial late gadolinium enhancement ≥10% was significantly associated with an increased rate of new-onset atrial arrhythmia compared to <10% (HR 3.16).
Cohort (n=111)
No
Does elevated left atrial late gadolinium enhancement (≥10%) on CMR predict new-onset atrial arrhythmia in patients with cardiac disease?
Elevated left atrial late gadolinium enhancement (≥10%) on CMR is an independent predictor of new-onset atrial arrhythmias and correlates with reduced left atrial and left ventricular diastolic function.
Estimación del efecto: HR 3.16 (95% CI 1.14-8.72)
valor p: p=0.026
BACKGROUND: Left atrial (LA) late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) imaging is indicative of fibrosis, and has been correlated with reduced LA function, increased LA volume, and poor procedural outcomes in cohorts with atrial fibrillation (AF). However, the role of LGE as a prognostic biomarker for arrhythmia in cardiac disease has not been examined. METHODS: In this study, we assessed LA LGE using a 3D LGE CMR sequence to examine its relationships with new onset atrial arrhythmia, and LA and left ventricular (LV) mechanical function. RESULTS: LA LGE images were acquired in 111 patients undergoing CMR imaging, including 66 patients with no prior history of an atrial arrhythmia. During the median follow-up of 2.7 years (interquartile range (IQR) 1.8-3.7 years), 15/66 (23%) of patients developed a new atrial arrhythmia. LA LGE ≥10% of LA myocardial volume was significantly associated with an increased rate of new-onset atrial arrhythmia, with a hazard ratio of 3.16 (95% CI 1.14-8.72), p = 0.026. There were significant relationships between LA LGE and both LA ejection fraction (r = - 0.39, p < 0.0005) and echocardiographic LV septal e' (r = - 0.24, p = 0.04) and septal E/e' (r = 0.31, p = 0.007). CONCLUSIONS: Elevated LA LGE is associated with reduced LA function and reduced LV diastolic function. LA LGE is associated with new onset atrial arrhythmia during follow-up.
Quail et al. (Tue,) conducted a cohort in Pre-existing cardiac disease (n=111). Left atrial late gadolinium enhancement (LA LGE) ≥10% vs. LA LGE <10% was evaluated on New-onset atrial arrhythmia (HR 3.16, 95% CI 1.14-8.72, p=0.026). Left atrial late gadolinium enhancement ≥10% was significantly associated with an increased rate of new-onset atrial arrhythmia compared to <10% (HR 3.16).