Previous anterior MI was associated with elevated plasma (95 vs 26 pg/ml, P<0.01) and pericardial fluid BNP (473 vs 57 pg/ml, P<0.001) compared to no MI, even with normal LV systolic function.
Observational (n=37)
Are plasma and pericardial fluid ANP and BNP concentrations elevated in patients with previous myocardial infarction undergoing coronary bypass surgery?
Previous anterior myocardial infarction is associated with increased cardiac BNP production, reflected in high pericardial fluid BNP concentrations, even when left ventricular systolic function is normal.
AIMS: In the present study we examined plasma and pericardial fluid ANP and BNP concentrations in postinfarction ventricular dysfunction. The association of peptide levels to left ventricular (LV) dysfunction and to the localization of the myocardial infarction (MI) was studied. METHODS AND RESULTS: Plasma and pericardial fluid samples were obtained from 37 patients undergoing coronary bypass surgery. According to the ECG and preceding coronary angiography, the patients were divided into three groups: previous anterior myocardial infarction (MI) (n=12), previous inferior/posterior MI (n=15) and no history of MI (n=10). When compared to the control group with no MI, the patients with anterior MI had elevated plasma ANP and BNP (134+/-13 vs. 81+/-15 pg/ml, P or =45%. Despite their normal LV systolic function, these patients had increased plasma and pericardial fluid BNP levels when compared to the group with no history of MI (68+/-18 pg/ml vs. 26+/-8 pg/ml, P or =45%). The high pericardial fluid BNP concentrations in postinfarction patients suggest that the BNP synthesis and release are augmented in the ventricular myocardium independent from the LVEF.
Klemola et al. (Mon,) conducted a observational in Postinfarction ventricular dysfunction (n=37). Previous anterior myocardial infarction vs. No history of myocardial infarction was evaluated on Plasma and pericardial fluid ANP and BNP concentrations. Previous anterior MI was associated with elevated plasma (95 vs 26 pg/ml, P<0.01) and pericardial fluid BNP (473 vs 57 pg/ml, P<0.001) compared to no MI, even with normal LV systolic function.