January 1, 1989Open Access
Ver artículo completoViral proteins containing the purine NTP-binding sequence pattern
Resultado clave
Viral proteins containing the evolutionarily conserved NTP-binding sequence pattern are non-randomly distributed and likely function as NTPases involved in DNA/RNA replication and packaging.
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Población
Viral proteins containing the purine NTP-binding sequence pattern
Viral proteins with conserved NTP-binding patterns are likely NTPases involved in key viral processes such as replication, transcription, and DNA packaging.
Resumen
A compilation is presented of viral proteins containing the NTP-binding sequence pattern, and criteria are suggested for assessment of the functional significance of the occurrence of this pattern in protein sequences. It is shown that the distribution of NTP-binding pattern-containing proteins through the viral kingdom is strongly non-random. Sequence comparisons led to delineation of several families of these proteins, some of which could be brought together into superfamilies including also cellular proteins. The available biochemical evidence is compatible with the proposal that viral proteins in which the NTP-binding pattern is evolutionarily conserved might all be NTPases involved in: i) duplex unwinding during DNA and RNA replication, transcription, recombination and repair, and possibly mRNA translation; ii) DNA packaging, and iii) dNTP generation.