Total Synthesis of (+)‐Gliocladin C Enabled by Visible‐Light Photoredox Catalysis

Lighting the way: In a 10-step total synthesis of the title compound, visible-light photoredox catalysis enabled the construction of the key bond by facilitating the direct coupling of a pyrroloindoline-derived radical with a substituted indole (see scheme; Boc=tert-butyloxycarbonyl, Cbz=benzyloxycarbonyl, DMF=N,N′-dimethylformamide). This represents the first implementation of visible-light photoredox catalysis in a total synthesis.