The oral salt loading test was associated with significantly higher nocturnal and 24-hour systolic blood pressure and urine albumin excretion in positive versus negative patients.
Observational (n=113)
No
Does the oral salt loading test (OSLT) associate with 24-hour blood pressure and organ damage in patients with primary aldosteronism?
The oral salt loading test is a potentially useful confirmatory test for primary aldosteronism that also reflects the severity of 24-hour systolic blood pressure and organ damage.
OBJECTIVE: In the present study, we investigated the most useful confirmatory test for reflecting the severity of primary aldosteronism (PA), by evaluating 24-hour blood pressure (BP), urine albumin, left ventricular mass (LVM), and intima media thickness (IMT). METHODS: This study included 113 patients (80 PA and 33 non-PA hypertensive patients) who were admitted to Oita University Hospital and evaluated using ambulatory blood pressure monitoring (ABPM). First, casual blood pressure (BP) and ABPM parameters were compared between PA and non-PA patients. Second, patients were divided into PA-positive and PA-negative groups based on confirmatory tests, including the saline infusion test (SIT), captopril challenge test (CCT), and oral salt loading test (OSLT), and casual BP and ABPM parameters were compared between the 2 groups. In addition, urine albumin excretion, LVM, and maximum IMT as markers of organ damage were compared between the 2 groups. RESULTS: The ABPM parameters but not casual BP, were higher in PA patients than in non-PA patients. Nocturnal and 24-hour systolic BP (SBP) in OSLT-positive patients were significantly higher than in OSLT-negative patients. ABPM parameters in other confirmatory tests were not different between the PA-positive and PA-negative groups. Urine albumin excretion in OSLT-positive patients was significantly higher than in the OSLT-negative patients. However, in other confirmatory tests, organ damage markers were not different between the 2 groups. CONCLUSION: The OSLT is potentially useful not only for the diagnosis of PA but also for assessment of 24-hour SBP and organ damage, as indicated by urine albumin excretion.
Yoshida et al. (Mon,) conducted a observational in Primary aldosteronism and hypertension (n=113). Oral salt loading test (OSLT) vs. OSLT-negative patients was evaluated on 24-hour blood pressure and organ damage markers (urine albumin excretion, left ventricular mass, and intima media thickness). The oral salt loading test was associated with significantly higher nocturnal and 24-hour systolic blood pressure and urine albumin excretion in positive versus negative patients.