The IL-10 rs1800872 CC genotype was associated with a significantly increased risk of valvular calcification in the Han population (adjusted OR 2.565) compared to the AC+AA genotypes.
Case-Control (n=1,065)
Sí
Estimación del efecto: OR 2.565 (95% CI 1.699-3.874)
Tasa de eventos absoluta: 33% vs 15.3%
valor p: p=<0.001
OBJECTIVE: Valvular calcification occurs via ongoing endothelial injury associated with inflammation. IL-10 is an anti-inflammatory cytokine and 75% of the variation in IL-10 production is genetically determined. However, the relationship between genetic polymorphisms of IL-10 and valvular calcification has not been studied. The objective of this study was to investigate the association between valvular calcification and IL-10 genetic polymorphisms in the Han, Uygur and Kazak populations in China. PATIENTS AND METHODS: All of the participants were selected from subjects participating in the Cardiovascular Risk Survey (CRS) study. The single nucleotide polymorphisms (SNPs) rs1800871 and rs1800872 of the IL-10 gene were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Three independent case-control studies involving the Han population, the Uygur population and the Kazak population were used in the analysis. RESULTS: For the Han and Kazak populations, rs1800871 was found to be associated with valvular calcification in the recessive model, and the difference remained statistically significant following multivariate adjustment (p<0.001, p=0.031, respectively). For the Han, Uygur and Kazak populations, rs1800872 was found to be associated with valvular calcification in the dominant model, and the difference remained statistically significant following multivariate adjustment (p<0.001, p=0.009, and p=0.023,respectively). CONCLUSION: Both rs1800871 and rs1800872 of the IL-10 gene are associated with valvular calcification in the Han and Kazak populations in China. Rs1800872 is also associated with valvular calcification in the Uygur population.
An et al. (Wed,) conducted a case-control in Valvular calcification (n=1,065). IL-10 rs1800872 polymorphism (CC genotype) vs. IL-10 rs1800872 polymorphism (AC+AA genotypes) was evaluated on Valvular calcification associated with IL-10 rs1800872 dominant model in the Han population (OR 2.565, 95% CI 1.699-3.874, p=<0.001). The IL-10 rs1800872 CC genotype was associated with a significantly increased risk of valvular calcification in the Han population (adjusted OR 2.565) compared to the AC+AA genotypes.