In young patients aged 40 years or below with acute coronary syndrome, dyslipidemia was present in 40.3% of cases and was associated with significantly higher rates of in-hospital post-MI angina compared to normolipidemic patients.
Observational (n=223)
No
Does dyslipidemia affect the clinical presentation and short-term outcomes in young patients (≤40 years) with acute coronary syndrome?
In young patients (≤40 years) with ACS, dyslipidemia is common but does not significantly impact short-term clinical outcomes or the extent of coronary artery disease.
Tasa de eventos absoluta: 21.35% vs 9.09%
valor p: p=<0.05
Background: Acute coronary syndrome (ACS) refers to a group of clinical symptoms compatible with acute myocardial ischemia and includes unstable angina, non-ST segment elevation myocardial infarction and ST-segment elevation myocardial infarction. Aims and Objectives: To study the incidence of lipid profile abnormalities in young patients (age 40 years or below) with ACS with clinical and cardiovascular risk profile. Material and Methods: The study was conducted on 223 young patients of acute coronary syndrome with age 40 years or below. 89 young patients with acute coronary syndrome having lipid abnormalities were further followed up after 1 month. Results: Majority of patients (55.15%) in the study population belonged to 35-40 years age group. Mean age of study population was 35.65 + 4.62 years with 90.13% males and 9.86% females. Main presenting symptom was precordial chest pain in 93.72% patients. Smoking was the commonest risk factor in young adults (81.7%). Other risk factors like diabetes, hypertension, family history were less common in young adults. Drug addiction was also higher in younger population (16%). Majority of young adults with acute coronary syndrome had more than 1 (47.53%) risk factor. Majority of patients were in Killip class I (86.9%) and only few patients (13.1%) had Killip class II or above. ST elevation myocardial infarction was far more common than NTEMI/USA and was found in 164 (73.5%) patients. Most common type of infarction was anterior wall myocardial infarction (62.80%). Majority of young patients had negative TMT, so it suggests that ACS in younger population has lesser complications during presentation, hospital stay and on follow-up. Conclusion: ACS in young continues to increase in Indian subcontinent. Younger patient with an ACS have different clinical characteristics and a different prognosis than older patients. The extent of CAD and degree of myocardial necrosis has influence on presentation and subsequent MACE in ACS and in this study, it appears dyslipidemia do not play any significant role in influencing extent of CAD and has little effect on outcome whether during acute stage or on immediate follow-up after ACS.
Fotedar et al. (Wed,) conducted a observational in Acute coronary syndrome (n=223). Dyslipidemia vs. Normolipidemia was evaluated on Post-MI angina during hospital stay (p=<0.05). In young patients aged 40 years or below with acute coronary syndrome, dyslipidemia was present in 40.3% of cases and was associated with significantly higher rates of in-hospital post-MI angina compared to normolipidemic patients.