Baseline high carotid intima-media thickness was associated with global cognitive decline, with a stronger association in White (p<0.001) than in Black (p=0.009) participants (interaction p=0.043).
Cohort
Is common carotid intima-media thickness associated with cognitive decline, and does race modify this association?
Carotid intima-media thickness is a predictor of cognitive decline, but its prognostic value is significantly stronger in White individuals compared to Black individuals.
valor p: p=<0.001
INTRODUCTION: Common carotid intima-media thickness (cIMT) is a marker of subclinical atherosclerosis and is associated with cognitive decline. Although carotid atherosclerosis is more frequent in White than in Black participants, little is known whether race modifies the association between cIMT and cognitive decline. METHODS: In this longitudinal analysis of the ELSA-Brasil, we assessed cIMT using ultrasound and cognitive performance using different domain tests. We used linear mixed models, interaction analysis, and race stratified analyses. RESULTS: Baseline high IMT values were associated with memory (p < 0.001), verbal fluency (p < 0.001), TMT-B (p < 0.001)), and global cognitive decline (p < 0.001). Race was an effect modifier in the association between IMT and global cognitive decline (0.043), with stronger association in White (p < 0.001) than in Black (p = 0.009) participants. DISCUSSION: Baseline IMT was associated with global and domain-specific cognitive decline and race modified this relationship, with stronger associations in White participants. HIGHLIGHTS: Carotid intima-media thickness (cIMT) was associated with cognitive decline. cIMT and cognitive decline association was stronger in White than in Black participants. We used inverse probability weighting to address attrition bias.
Ferreira et al. (Fri,) conducted a cohort in Cognitive decline. High carotid intima-media thickness (cIMT) vs. Low cIMT was evaluated on Global cognitive decline (p=<0.001). Baseline high carotid intima-media thickness was associated with global cognitive decline, with a stronger association in White (p<0.001) than in Black (p=0.009) participants (interaction p=0.043).