Why the study?
Does pre-existing non-severe functional mitral regurgitation affect postoperative outcomes and improve after isolated aortic valve replacement in patients with severe aortic stenosis?
Population
577 consecutive patients with severe aortic valve stenosis undergoing isolated aortic valve replacement…
Comparison
Isolated aortic valve replacement vs Patients without pre-existing non-severe…
Design
Cohort
Follow-up
prior to hospital discharge
Key result
Pre-existing non-severe functional mitral regurgitation in patients undergoing isolated aortic valve replacement was associated with greater morbidity and mortality (10.5% vs 5.6%; p=0.025).
Authors
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Should not yet alter isolated AVR strategy; leaves open whether concomitant mitral intervention improves survival.
Cohort (n=577)
Does pre-existing non-severe functional mitral regurgitation affect postoperative outcomes and improve after isolated aortic valve replacement in patients with severe aortic stenosis?
Non-severe functional mitral regurgitation in patients undergoing isolated aortic valve replacement increases perioperative morbidity and mortality, though it frequently improves or resolves in survivors.
Absolute Event Rate: 10.5% vs 5.6%
p-value: p=0.025
Caballero‐Borrego et al. (2008) conducted a cohort in severe aortic stenosis (n=577). Pre-existing non-severe functional mitral regurgitation vs. Absence of pre-existing non-severe functional mitral regurgitation was evaluated on morbidity and mortality (p=0.025). Pre-existing non-severe functional mitral regurgitation in patients undergoing isolated aortic valve replacement was associated with greater morbidity and mortality (10.5% vs 5.6%; p=0.025).