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TAMable tumor-associated macrophages in response to innate RNA sensing | Synapse

April 20, 2012Open Access

TAMable tumor-associated macrophages in response to innate RNA sensing

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Antitumor effect of PolyI:C (a viral dsRNA analog) has been attributed to dendritic cell (DC)-maturation activity, that drives antitumor NK cells, DC cross-presentation, cytotoxic T lymphocytes and many IFN-inducible genes. According to a recent paper, tumor-infiltrating M2 macrophages are found to become an additional antitumor effector through polyI:C response.

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Seya et al. (Fri,) studied this question.

synapsesocial.com/papers/6a0cb96cfcb0a2efa52ca8ac https://doi.org/https://doi.org/10.4161/onci.19894

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