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July 5, 2018Open Access

An Immune System-Modified Rat Model for Human Stem Cell Transplantation Research

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(SG) rats, NSGL rats allow more efficient engraftment of human cancer cells and human pluripotent stem cells. In addition, only NSGL rats, but not SG rats, can be engrafted with human hematopoietic stem cells to reconstitute the human immune system. Therefore, NSGL rats represent an improved xenotransplantation model for efficacy studies of human stem cells.

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Cite This Study

Yang et al. (Thu,) studied this question.

synapsesocial.com/papers/6a0ce926df69d124d8026ad5 https://doi.org/https://doi.org/10.1016/j.stemcr.2018.06.004

An Immune System-Modified Rat Model for Human Stem Cell Transplantation Research | Synapse