A consensus document outlines best practices and rigorous methods for mechanistic model development, analysis, and calibration in cardiovascular research to improve reproducibility.
Computational, or in silico, models are an effective, noninvasive tool for investigating cardiovascular function. These models can be used in the analysis of experimental and clinical data to identify possible mechanisms of (ab)normal cardiovascular physiology. Recent advances in computing power and data management have led to innovative and complex modeling frameworks that simulate cardiovascular function across multiple scales. While commonly used in multiple disciplines, there is a lack of concise guidelines for the implementation of computer models in cardiovascular research. In line with recent calls for more reproducible research, it is imperative that scientists adhere to credible practices when developing and applying computational models to their research. The goal of this manuscript is to provide a consensus document that identifies best practices for in silico computational modeling in cardiovascular research. These guidelines provide the necessary methods for mechanistic model development, model analysis, and formal model calibration using fundamentals from statistics. We outline rigorous practices for computational, mechanistic modeling in cardiovascular research and discuss its synergistic value to experimental and clinical data.
Colebank et al. (Fri,) conducted a review in Cardiovascular research (computational modeling). In silico computational modeling guidelines was evaluated. A consensus document outlines best practices and rigorous methods for mechanistic model development, analysis, and calibration in cardiovascular research to improve reproducibility.