Alleviation of diabetic cardiomyopathy via preventing VCAM1-positive cells from senescence by engineered nanovesicles

Puntos clave

• The research aims to explore how targeting VCAM1-positive cells can prevent their senescence and improve cardiac health in diabetic conditions.
• Engineered nanovesicles were used to inhibit the transition of pre-senescent cells to a senescent state.
• Cardiac function and senescent burden were assessed in diabetic mice.
• VCAM1 was identified as a new marker for pre-senescent cells.
• Targeted strategy significantly reduced overall senescent burden in the diabetic heart.
• Cardiac microvascular injury was markedly improved following intervention.
• Cardiac function was significantly enhanced in treated diabetic mice.