A multiscale growth and remodeling model accurately captured progressive changes in pulmonary arterial pressure, wall thickness, and stiffness in monocrotaline-induced pulmonary hypertension (R² > 0.9).
A multiscale growth and remodeling model accurately captures the progression of MCT-induced pulmonary vascular remodeling, providing a computational foundation for predicting therapeutic outcomes in pulmonary hypertension.
Estimación del efecto: R² > 0.9
Abstract Rationale Pulmonary hypertension (PH) is a progressive disorder marked by increased pulmonary vascular resistance, right-ventricular hypertrophy, and high mortality. Despite extensive experimental research, the quantitative mechanisms linking elevated hemodynamic load to structural remodeling remain unclear. The monocrotaline (MCT) rat model reproduces many key features of human PH, including endothelial injury, inflammation, and medial thickening. Mechanistic growth and remodeling (G 0.9 for all metrics). Pressure increased nonlinearly with progression (Figure 1B), stiffness amplification reflected collagen accumulation and smooth muscle activation (Figure 1C), and wall thickness showed an exponential rise (Figure 1D). These simulations focused on matching observed increases in pressure, wall thickness, and stiffness by tuning parameters associated with constituent mass production and vessel narrowing within the constrained mixture framework. The model’s consistent agreement with multiple experimental datasets shows its ability to capture key hemodynamic features of disease progression and provides a strong foundation for future studies aimed at quantifying reversibility and therapeutic efficacy. Conclusions This multiscale G&R model captures the progression of MCT-induced pulmonary vascular remodeling by linking cellular activation and matrix turnover to network-level adaptation. These findings highlight the potential of G&R modeling to unify diverse remodeling mechanisms and predict therapeutic outcomes in pulmonary hypertension. This abstract is funded by: None
Jahani et al. (Fri,) conducted a other in Pulmonary hypertension. Multiscale growth and remodeling (G&R) model vs. Experimental MCT data was evaluated on Temporal changes in pressure, wall thickness, and stiffness (R² > 0.9). A multiscale growth and remodeling model accurately captured progressive changes in pulmonary arterial pressure, wall thickness, and stiffness in monocrotaline-induced pulmonary hypertension (R² > 0.9).