Abstract Purpose The epidemiology and prognostic outcomes of COPD patients comorbid with psoriasis, atopic dermatitis, urticaria, and rosacea remain unclear. We aimed to clarify the incidence and risk factors of these skin diseases in COPD during follow-up, and to investigate their prevalence and survival impact in COPD. Patients and Methods We conducted a prospective study using UK Biobank data and established three cohorts: (1) a non-skin disease cohort comparing COPD and non-COPD individuals to assess the incidence of inflammatory skin diseases (Cohort 1, n = 182,177); (2) a baseline cohort to estimate their prevalence (Cohort 2, n = 160,863); and (3) a survival cohort of COPD patients to evaluate prognostic outcomes (Cohort 3, n = 5,191). Cox regression models were used to compare risks of the mortality. Results During a median follow-up of 15.4 years, the incidence of psoriasis (1.43% vs. 0.98%) and atopic dermatitis (1.57% vs. 1.01%) was significantly higher in COPD compared to non-COPD in cohort 1, whereas not for urticaria or rosacea. After adjustment for covariates, Cox regression analysis indicated that males, individuals who are obese or overweight, as well as former smokers or current smokers, and those with an FEV1%predicted less than 80% had a significantly higher risk of psoriasis. A lower FEV1.Z score was also associated with an increased risk. Besides, neither model 1 nor model 2 demonstrated a clear association between COPD and the risk of psoriasis. The Cox regression results for atopic dermatitis were similar to those for psoriasis. In Cohort 2, the prevalence of psoriasis (3.27% vs. 2.33%) and atopic dermatitis (2.97% vs. 2.28%) was higher in individuals with COPD than in those without COPD at baseline. After a median follow-up of 15.7 years in COPD, the presence of these four aforementioned inflammatory skin diseases did not increase the risk of all-cause mortality among COPD patients. Conclusion COPD patients have a higher incidence of psoriasis and atopic dermatitis than non-COPD patients, but not for urticaria or rosacea. Male, ever smokers, overweight or obese individuals, and those with low FEV1 have a higher risk of developing psoriasis and atopic dermatitis. Yet, no increased mortality risk from COPD has been linked to these inflammatory skin diseases. This abstract is funded by: National Natural Science Foundation of China
Cheng et al. (Fri,) studied this question.