Depression and anxiety were frequent in PAH patients (28.4% and 42.9%) and depression scores significantly correlated with decreased quality of life (EmPHasis-10 and PHQ-9: r=0.638, p=0.002).
Cross-Sectional (n=21)
No
Depression and anxiety are frequent in patients with PAH and significantly correlate with decreased quality of life and functional capacity.
Estimación del efecto: r = 0.638
valor p: p=0.002
Abstract Rationale Pulmonary hypertension is an increase in mean pulmonary artery pressure (PAPm) above 20 mmHg. Pulmonary arterial hypertension (PAH) is defined by the precapillary form, excluding the existence of other causes, such as lung diseases, pulmonary thromboembolism or other rare entities. Depression is increasingly recognized as a comorbidity in patients with PAH, but its relationship with quality of life and clinical parameters remains incompletely explored. Methods We conducted an observational, cross-sectional study at the “Marius Nasta” Institute of Pulmonology in Bucharest. The PHQ-9 (Patient Health Questionnaire-9) and HADS-D/A (Hospital Anxiety and Depression Scale) questionnaires were used to assess depression, and the EmPHasis-10 questionnaire was used to assess quality of life. Clinical data were also taken from the patients’ medical records. Results So far, 21 patients have been included. Fourteen were female (66.7%) and the mean age was 52.7 ± 16.7 years. The majority of patients had idiopathic PAH (42.9%) and PAH associated with connective tissue diseases (33.3%). 4 patients were functional class (FC) I (19%), 9 were FC II (42.9%) and 8 were FC III (38.1%). The mean Emphasis, PHQ-9, HADS-D and HADS-A scores were 16.95 ± 13.05, 7.62 ± 5.81, 4.95 ± 4.64, and 6.90 ± 5.10, respectively. According to the HADS results, 6 patients (28.4%) met the criteria for depression, while 9 patients (42.9%) were classified as having anxiety. Correlation analysis was performed between depression scores and quality of life, thus we obtained a significant association between EmPHasis-10 and PHQ-9 (r = 0.638, p = 0.002) and HADS-D (r = 0.608, p = 0.003). A moderate negative correlation was observed between EmPHasis-10 and 6MWD (r = -0.527, p = 0.014) and a positive, but statistically non-significant, correlation was obtained between depression and functional class (ρ = 0.388, p = 0.082). Conclusions These results highlight the fact that depression and anxiety are frequent in patients with PAH and are correlated with the decreased quality of life and functional capacity. The present study is one of the first to analyze the relationship between HADS score and EmPHasis. The research is ongoing, and the number of participating patients is expected to increase. This abstract is funded by: None
Costan et al. (Fri,) conducted a cross-sectional in Pulmonary arterial hypertension (PAH) (n=21). Depression and anxiety were frequent in PAH patients (28.4% and 42.9%) and depression scores significantly correlated with decreased quality of life (EmPHasis-10 and PHQ-9: r=0.638, p=0.002).