A BMI decrease of >10% was associated with a significantly higher risk of all-cause mortality (aHR 1.86) and cardiovascular disease-related mortality (aHR 2.20) compared to a stable BMI.
Cohort (n=90,258)
Does a change in body mass index (BMI) over time increase the risk of all-cause and cardiovascular disease-related mortality in adults without baseline cardiovascular disease?
Significant fluctuations in BMI, particularly a decrease of >10% or an increase of >10% in obese individuals, are associated with increased risks of all-cause and cardiovascular mortality, highlighting the need for clinical evaluation in these patients.
Estimación del efecto: aHR 1.86 (95% CI 1.43-2.43)
Tasa de eventos absoluta: 3.7% vs 2.4%
BACKGROUND: The impact of changes in body mass index (BMI) on the risk of all-cause and cardiovascular disease (CVD)-related mortality has not been extensively studied. We examined whether changes in BMI status over time are associated with risk of all-cause and CVD-related mortality. METHODS: This longitudinal study recruited 90,258 adults between 2002 and 2008 from the Taiwan MJ cohort who underwent repeated BMI measurements at an interval of 3.3 years and were followed up for all-cause and CVD-related mortality over 12.1 years. Cox proportional hazard and Fine-Gray sub-distribution hazard models with death from non-CVD causes as the competing risk was used to determine the impact of changes in BMI status on the risk of all-cause or CVD-related mortality, respectively. RESULTS: Over 1,094,606 person-years of follow-up, 2,084 participants died, including 391 (18.8%) CVD-related deaths. After adjusting for other covariates, the risks of all cause (adjusted hazard ratio aHR, 1.86; 95% confidence interval CI, 1.43-2.43) and CVD-related (aHR, 2.20; 95% CI, 1.24-3.93) mortalities were significantly higher in those with a BMI decrease of > 10% than in those with stable BMI. Participants with obesity at baseline who had BMI increase of > 10% during the follow-up period had a significantly higher risk of all-cause (aHR = 2.30; 95% CI:1.38-3.85) and CVD-related mortality (aHR = 3.44; 95% CI:1.33-8.89). CONCLUSIONS: A BMI decrease of > 10% was associated with a high risk of all-cause and CVD-related mortalities. Thus, those experiencing significant BMI decreases should undergo a comprehensive evaluation to mitigate mortality risks.
Lai et al. (Thu,) conducted a cohort in All-cause and cardiovascular disease-related mortality (n=90,258). BMI decrease of > 10% vs. Stable BMI (< 5% change) was evaluated on All-cause mortality (aHR 1.86, 95% CI 1.43-2.43). A BMI decrease of >10% was associated with a significantly higher risk of all-cause mortality (aHR 1.86) and cardiovascular disease-related mortality (aHR 2.20) compared to a stable BMI.