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Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters | Synapse

June 5, 2019Open Access

Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters

Donald M. BersElectrophysiology YXYang XiangNanjing Agricultural University MZManuela ZaccoloHeart Failure & Transplant

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Resumen

Novel targeted fluorescent biosensors provide key insights into very local nanodomains of cAMP and PKA activity, and how they respond differently to β-adrenergic activation in cardiac myocytes. This unique spatiotemporal detail in living cells is not available with biochemical measurements of total cellular cAMP and PKA, and provides unique physiological insights.

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Cite This Study

Bers et al. (Wed,) studied this question.

synapsesocial.com/papers/6a0e9ecc25c30b2cc7f99dda https://doi.org/https://doi.org/10.1152/physiol.00002.2019