Mean left atrial bipolar voltage was significantly lower during atrial fibrillation compared to sinus rhythm (1.0 mV vs. 2.6 mV, p<0.01), indicating that CFAEs and high DF areas do not reflect damaged atrial myocardium.
Observational (n=16)
No
Do complex fractionated atrial electrograms and high dominant frequency sites reflect low voltage substrates during sinus rhythm in patients with atrial fibrillation?
CFAEs and high DF areas during AF do not reflect damaged atrial myocardium as shown by sinus rhythm voltage, but they demonstrate different electrophysiologic properties during AF.
Tasa de eventos absoluta: 1% vs 2.6%
valor p: p=<0.01
Abstract Background Ablation targeting complex fractionated atrial electrograms (CFAEs) or high dominant frequency (DF) sites is generally effective for persistent atrial fibrillation (AF). CFAEs and/or high DF sites may exist in low‐voltage regions, which theoretically represent abnormal substrates. However, whether CFAEs or high DF sites reflect low voltage substrates during sinus rhythm (SR) is unknown. Methods Sixteen patients with AF (8 with paroxysmal AF; 8, persistent AF) underwent high‐density mapping of the left atrium (LA) with a 3‐dimensional electroanatomic mapping system before ablation. The LA was divided into 7 segments and the mean bipolar voltage recorded during AF and SR, CFAEs (cycle lengths of 50–120 ms), and DF sites were assessed in each segment with either a duo‐decapolar ring catheter (n=10) or a 64‐pole basket catheter (n=6). Low‐voltage areas were defined as those of 8 Hz) did not correlate with % low‐voltage sites during SR; however, CFAEs sites were located in high‐voltage regions during AF and high DF sites were located in low voltage regions during AF. Conclusions CFAEs and high DF areas during AF do not reflect damaged atrial myocardium as shown by the SR voltage. However, CFAEs and high DF sites may demonstrate different electrophysiologic properties because of different voltage amplitude during AF.
Sasaki et al. (Thu,) conducted a observational in Atrial fibrillation (n=16). Left atrial mapping during atrial fibrillation vs. Left atrial mapping during sinus rhythm was evaluated on Mean bipolar voltage (p=<0.01). Mean left atrial bipolar voltage was significantly lower during atrial fibrillation compared to sinus rhythm (1.0 mV vs. 2.6 mV, p<0.01), indicating that CFAEs and high DF areas do not reflect damaged atrial myocardium.
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