Advancing age from 7-20 to 60-80 years was associated with increased left ventricular muscle mass index and ejection fraction (P<0.0001), and decreased end-diastolic volume index (P<0.0001).
Observational (n=5,307)
How do age and gender affect left ventricular size, muscle mass, and systolic function in subjects with normal echocardiograms?
Normal left ventricular parameters undergo lifelong remodeling, with ejection fraction, fractional shortening, and muscle mass index increasing and end-diastolic volume index decreasing with advancing age, particularly in females.
valor p: p=<0.0001
BACKGROUND: The effect of age and gender on left ventricular (LV) size, muscle mass, and systolic function as determined by two-dimensional echocardiography has not yet been investigated in a large population. METHODS: Normal transthoracic two-dimensional echocardiography studies of 5307 subjects (47% males) performed between March 1990 and December 2011 were analyzed. LV end-diastolic volume index (LVEDVI), LV muscle mass index (LVMMI), LV ejection fraction (LVEF), and LV fractional shortening (LVFS) were compared in different age groups. RESULTS: LVMMI increased in females from 66.4 ± 1.3 g/m(2) (7-20 years) to 76.3 ± 0.9 g/m(2) (60-80 years; P < 0.0001) and in males from 81.9 ± 1.7 g/m(2) (7-20 years) to 94.6 ± 1.3 g/m(2) (60-80 years; P < 0.0001). LVEDVI decreased in females from 49.8 ± 0.9 mL/m(2) (7-20 years) to 42.8 ± 0.6 mL/m(2) (60-80 years; P < 0.0001) and in males from 56.6 ± 0.8 mL/m(2) (7-20 years) to 49.0 ± 0.7 mL/m(2) (60-80 years; P < 0.0001). A significant increase in LVEF was observed with age (P < 0.0001 for both genders), but it was more pronounced in females (62 ± 0.5% age 7-20 years vs. 65 ± 0.3% age 60-80 years) than in males (62 ± 0.5% age 7-20 years vs. 64 ± 0.3% age 60-80 years). Similarly, LVFS increased in females from 37.7 ± 0.5% (7-20 years) to 42.4 ± 0.4% (60-80 years; P < 0.001) and in males from 37.3 ± 0.5% (7-20 years) to 39.4 ± 0.5% (60-80 years; P < 0.001). CONCLUSIONS: LVEF, LVFS, and LVMMI increase with advancing age, in particular in females. In contrast, LVEDVI decreases with age. These findings indicate that the LV undergoes a lifelong remodeling.
Gebhard et al. (Thu,) conducted a observational in Normal echocardiography (n=5,307). Advancing age and gender was evaluated on Left ventricular end-diastolic volume index, muscle mass index, ejection fraction, and fractional shortening (p=<0.0001). Advancing age from 7-20 to 60-80 years was associated with increased left ventricular muscle mass index and ejection fraction (P<0.0001), and decreased end-diastolic volume index (P<0.0001).