In hypertensive women within 5 years post-menopause, the T/PRL-E2 ratio was significantly positively correlated with nighttime systolic blood pressure (r = 0.262).
Cross-Sectional (n=420)
No
Does sex hormone imbalance correlate with ambulatory blood pressure indices in hypertensive postmenopausal women compared to matched men?
Sex hormone imbalances in postmenopausal women with hypertension are significantly correlated with ambulatory blood pressure parameters, particularly nocturnal systolic blood pressure, varying by menopausal duration.
Estimación del efecto: r = 0.262
valor p: p=0.029
Abstract Background The prevalence of hypertension in postmenopausal women increases significantly compared to premenopausal women and gradually catches up with, or even exceeds, that of their male counterparts. Imbalanced levels of sex hormones play a critical role in the elevation of blood pressure (BP) observed in this population. Furthermore, blunted nocturnal BP decline is a key factor contributing to their increased cardiovascular risk. This study compared ambulatory blood pressure (ABP) values between female hypertensive patients with different menopausal durations and matched male patients, aiming to explore the correlation between sex hormone imbalance and ABP values. Methods This cross-sectional study included 210 postmenopausal women and 210 matched male patients. The male patients were matched to hypertensive female patients with varying menopausal durations on the basis of variables such as age, body mass index (BMI, kg/m 2 ), hypertension duration, antihypertensive medication use and metabolism-related indicators. Clinical characteristics, Ambulatory Blood Pressure Monitoring (ABPM), and sex hormone levels were evaluated. Quantitative data were analyzed using one-way analysis of variance and multiple regression analysis. Results Compared with matched men, in women with hypertension within 5 years after menopause, the T/PRL–E 2 was associated with nighttime SBP. In those with menopausal durations of 6–10 years, the FSH/T ratio is associated with the absence of significant differences in 24-h SBP and daytime SBP relative to matched men, while the PRL/FSH ratio is negatively correlated with nighttime SBP in this group. In hypertensive women with menopausal durations of 11–15 years, the PRL-E 2 /T ratio is linked to 24-h, daytime and nighttime SBPs. In contrast, correlations involving diastolic blood pressure (DBP) indices displayed a distinct pattern. The FSH/PRL ratio shows a protective association with all mean DBP parameters in hypertensive women with menopausal durations less than 5 years and 11–15 years, whereas the T/P ratio is positively associated with those with 6–10 years of menopause. Conclusions There was a significant correlation between sex hormone levels and ABP parameters, particularly nocturnal SBP, in women with different menopausal durations. Trial registration : This study was retrospectively registered on ClinicalTrials.gov (NCT03451747) on February 18, 2018.
Zhang et al. (Mon,) conducted a cross-sectional in Essential hypertension (n=420). Postmenopausal status with varying durations vs. Age-matched hypertensive males was evaluated on Correlation between T/PRL-E2 ratio and nighttime systolic blood pressure in women <=5 years post-menopause (r = 0.262, p=0.029). In hypertensive women within 5 years post-menopause, the T/PRL-E2 ratio was significantly positively correlated with nighttime systolic blood pressure (r = 0.262).