Why the study?
Understanding nucleus sensing and sarcomeric protein dysfunction may clarify functional responses in cardiomyopathic disease progression.
Design
Review
Key result
Mechanotransduction in cardiomyocytes transmits mechanical signals to the nucleus, resulting in changes in gene expression and morphology that may contribute to cardiomyopathic diseases.
Authors
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Nuclear mechanosensing may underlie cardiomyopathy progression; leaves open whether targeting it alters clinical outcomes.
Understanding nuclear mechanosensing in cardiomyocytes provides insight into the pathophysiological development of cardiac dysfunction and cardiomyopathies.
Coscarella et al. (2023) conducted a review in Cardiomyopathic diseases. Nucleus mechanosensing was evaluated. Mechanotransduction in cardiomyocytes transmits mechanical signals to the nucleus, resulting in changes in gene expression and morphology that may contribute to cardiomyopathic diseases.