Advances in ceRNA regulatory networks in adipogenesis: Mechanistic insights and future perspectives

Adipogenesis, as a key process in the development of adipose tissue, occurs within a complex and precisely regulated molecular network. In recent years, competing endogenous RNA (ceRNA) has emerged as a cutting-edge research focus in adipogenesis through the formation of regulatory networks based on shared microRNA response elements (MREs). This article provides a narrative review of recent progress on the regulatory roles of ceRNA networks in adipogenesis and adipose tissue development. It reviews the theoretical framework of the ceRNA hypothesis, analyzes the composition of ceRNA network components, and explains their important biological functions. Particular emphasis is placed on the regulatory mechanisms of ceRNA in adipocyte differentiation and adipose tissue development. Furthermore, the main experimental approaches and analytical methods currently used for ceRNA research are summarized and discussed. This review aims to provide an integrated understanding of ceRNA-mediated regulatory networks in adipogenesis and to offer valuable references for future research in this field. • This review summarizes the ceRNA regulatory framework and its core components in adipogenesis. • lncRNAs, circRNAs, pseudogenes, and mRNAs are discussed as key ceRNA regulators of adipocyte differentiation. • The complexity, adipose tissue specificity, and epigenetic integration of ceRNA networks are highlighted. • A stepwise validation framework for adipogenic ceRNA studies is proposed to improve methodological rigor. • The translational value of ceRNA-guided biomarkers and RNA-based therapeutic strategies is discussed.