Verity plots provided insights into statistical properties, outlier detection, and parametric test assumptions, outperforming Correlation, Box, and Bland-Altman plots for assessing AI-expert agreement.
Artificial intelligence (AI) methods for automated quantification of ventricular volumes, function, and myocardial tissue characterization in cardiovascular magnetic resonance (CMR)
Verity plots (a novel statistical visualization merging reliability plots with density and scatter plots)
Correlation, Box and Bland-Altman plots
Utility in communicating reliability, bias, variance, trends, outliers, and AI-expert agreement
Verity plots offer a novel and superior visualization tool compared to traditional plots for assessing and communicating the reliability and agreement of AI quantification methods in cardiovascular magnetic resonance.
BACKGROUND: Artificial intelligence (AI) methods have established themselves in cardiovascular magnetic resonance (CMR) as automated quantification tools for ventricular volumes, function, and myocardial tissue characterization. Quality assurance approaches focus on measuring and controlling AI-expert differences but there is a need for tools that better communicate reliability and agreement. This study introduces the Verity plot, a novel statistical visualization that communicates the reliability of quantitative parameters (QP) with clear agreement criteria and descriptive statistics. METHODS: Tolerance ranges for the acceptability of the bias and variance of AI-expert differences were derived from intra- and interreader evaluations. AI-expert agreement was defined by bias confidence and variance tolerance intervals being within bias and variance tolerance ranges. A reliability plot was designed to communicate this statistical test for agreement. Verity plots merge reliability plots with density and a scatter plot to illustrate AI-expert differences. Their utility was compared against Correlation, Box and Bland-Altman plots. RESULTS: Bias and variance tolerance ranges were established for volume, function, and myocardial tissue characterization QPs. Verity plots provided insights into statstistcal properties, outlier detection, and parametric test assumptions, outperforming Correlation, Box and Bland-Altman plots. Additionally, they offered a framework for determining the acceptability of AI-expert bias and variance. CONCLUSION: Verity plots offer markers for bias, variance, trends and outliers, in addition to deciding AI quantification acceptability. The plots were successfully applied to various AI methods in CMR and decisively communicated AI-expert agreement.
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Thomas Hadler
Max Delbrück Center
Clemens Ammann
University of Bern
Hadil Saad
Max Delbrück Center
PLoS ONE
Charité - Universitätsmedizin Berlin
Humboldt-Universität zu Berlin
Freie Universität Berlin
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Hadler et al. (Fri,) conducted a other in Cardiovascular magnetic resonance (CMR) AI quantification. Verity plots vs. Correlation, Box and Bland-Altman plots was evaluated on AI-expert agreement and reliability visualization. Verity plots provided insights into statistical properties, outlier detection, and parametric test assumptions, outperforming Correlation, Box, and Bland-Altman plots for assessing AI-expert agreement.
synapsesocial.com/papers/6a0f72282badbc352afe2e8e — DOI: https://doi.org/10.1371/journal.pone.0323371