Long axis strain assessed by cardiovascular magnetic resonance was an independent predictor of cardiac events (HR 1.28) in patients with non-ischemic dilated cardiomyopathy.
Cohort (n=146)
No
Does left ventricular long axis strain (LAS) assessed by CMR predict cardiac events in patients with non-ischemic dilated cardiomyopathy?
Left ventricular long axis strain assessed by CMR provides significant incremental prognostic value beyond established parameters like LGE and LVEDV in patients with non-ischemic dilated cardiomyopathy.
Estimación del efecto: HR 1.28 (95% CI 1.07-1.52)
valor p: p=0.006
BACKGROUND: Long axis strain (LAS) has been shown to be a fast assessable parameter representing global left ventricular (LV) longitudinal function in cardiovascular magnetic resonance (CMR). However, the prognostic value of LAS in cardiomyopathies with reduced left ventricular ejection fraction (LVEF) has not been evaluated yet. METHODS AND RESULTS: In 146 subjects with non-ischemic dilated cardiomyopathy (NIDCM, LVEF ≤45 %) LAS was assessed retrospectively from standard non-contrast SSFP cine sequences by measuring the distance between the epicardial border of the left ventricular apex and the midpoint of a line connecting the origins of the mitral valve leaflets in end-systole and end-diastole. The final values were calculated according to the strain formula. The primary endpoint of the study was defined as a combination of cardiac death, heart transplantation or aborted sudden cardiac death and occurred in 24 subjects during follow-up. Patients with LAS values > -5 % showed a significant higher rate of cardiac events independent of the presence of late gadolinium enhancement (LGE). The multivariate Cox regression analysis revealed that LVEDV/BSA (HR: 1.01, p -10 % and the presence of LGE, patients with 3 points had a significantly higher risk for cardiac events than those with 2 or less points. CONCLUSION: Assessment of long axis function with LAS offers significant incremental information for the prediction of cardiac events in NIDCM and improves risk stratification beyond established CMR parameters.
Riffel et al. (Fri,) conducted a cohort in Non-ischemic dilated cardiomyopathy (n=146). Long axis strain (LAS) assessment vs. Standard CMR parameters was evaluated on Combination of cardiac death, heart transplantation or aborted sudden cardiac death (HR 1.28, 95% CI 1.07-1.52, p=0.006). Long axis strain assessed by cardiovascular magnetic resonance was an independent predictor of cardiac events (HR 1.28) in patients with non-ischemic dilated cardiomyopathy.