Metal organic framework based synergistic improvement of hypoxia for optimizing diabetic wounds healing

. During the early-stage repair processes, ZCZ can promote the proliferation, migration, and tubular formation of vascular endothelial cells, as well as neovascularization. Through an in vivo diabetic wound model, it was observed that ZCZ significantly reduced the wound healing time. It also enhanced the dermal thickness by increasing collagen deposition, along with elevating the presence of M2 macrophages, augmenting neovascularization, and improving the oxygen-carrying capacity. Mechanism studies have indicated that ZCZ mainly exerts its effects through inhibiting the IL6/JAK2/STAT3 pathway. Consequently, the proposed strategy not only offers a novel clinical option but also paves a new path for the management of chronic and recalcitrant wounds.