Deep Radiomic Analysis Based on Modeling Information Flow in Convolutional Neural Networks

This paper proposes a novel image feature set based on a principled information theoretic analysis of the convolutional neural network (CNN). The output of convolutional filters is modeled as a random variable conditioned on the object class and network filter bank. The conditional entropy (CENT) of filter outputs is shown in theory and experiments to be a highly compact and class-informative feature that can be computed from the CNN feature maps and used to obtain higher classification accuracy than the original CNN itself. Experiments involve three binary classification tasks using the 3D brain MRI data: Alzheimer's disease (AD) versus healthy controls (HC), young versus old age, and male versus female, where the area under the curve (AUC) values for the CENT feature classification (93.9%, 96.7%, and 71.9%) are significantly higher than the softmax output of the original CNN classifier trained for the task (81.6%, 79.4%, and 63.1%). A statistical analysis based on the Wilcoxon test identifies CENT features with significant links to brain labels, which could potentially serve as diagnostic biomarkers.