What is the clinical evidence from this study?

Study design: Observational. Population: Metabolic Syndrome (n=54). Intervention: Long-term exercise training vs. Non-exercising control group. Primary outcome: QT dispersion (QTd) (p=<0.01).

January 1, 2010Open Access

Long-Term Exercise-Training Improves QT Dispersion in the Metabolic Syndrome

Q: What are the key findings of this study?

Long-term exercise training significantly reduced QT dispersion from 66 to 56 ms in metabolic syndrome patients with coronary heart disease and from 58 to 51 ms in those without.

Resultado clave

Long-term exercise training significantly reduced QT dispersion from 66 to 56 ms in metabolic syndrome patients with coronary heart disease and from 58 to 51 ms in those without.

Diseño del estudio

Tipo

Observational (n=54)

Enmascaramiento

Single-blind

Multicéntrico

PICO estructurado

Does long-term exercise training improve QT dispersion in patients with metabolic syndrome?

Población

54 patients with metabolic syndrome (MS) defined by modified NCEP ATP III criteria, including 31 without coronary heart disease (CHD) and 23 with CHD. Mean age 57-65 years, predominantly male.

Intervención

Long-term (≥ 6 months) supervised aerobic exercise training and cardiac rehabilitation program (2 sessions/week, 40 mins/session at 65-90% max HR) plus 1-2 additional weekly sessions outside the center.

Comparador

Control group of 8 MS patients with CHD who decided not to undertake cardiac rehabilitation, followed with usual medical care.

Resultado

QT dispersion (QTd) measured on standard 12-lead resting ECG at baseline and end of follow-up.surrogate

Resultado numérico

Tasa de eventos absoluta: 56% vs 72%

valor p: p=<0.01

Limitaciones

Nonrandomized, observational, and retrospective study design
Small sample size, particularly for the control group
Most subjects were men
Measurements of QT interval were made manually

Resumen

Increased QT dispersion (QTd) is a marker of myocardial electrical instability and predicts ventricular arrhythmias and sudden cardiac death. Exercise training (ET) has been shown to reduce both QTd and cardiovascular mortality in various populations. Patients with metabolic syndrome (MS) have been shown to have increased QTd. The effect of ET on QTd in MS patients however is unknown. We sought to assess the effect of a long-term (> or = 6 months) ET program on QTd parameters in MS patients with and without coronary heart disease (CHD). Fifteen CHD and 31 non-CHD patients with MS (mean age, 64 +/- 7 and 57 +/- 9 years, respectively) were identified at entry into identical ET programs. MS was defined using modified National Cholesterol Education Program criteria. A control group consisted of 8 MS patients with CHD (mean age, 65 +/- 6 years). Ventricular repolarization (QT dispersion = QTd, standard deviation of QT = SDQT, relative dispersion of QT = RDQT, QT corrected dispersion = QTcd), metabolic and exercise parameters were measured before and after ET. Program duration was over 9 months (312 +/- 100 versus 284 +/- 101 days in CHD and non-CHD cohorts, P = NS). QTd decreased in both ET groups (QTd pre versus post = 66 versus 56 ms in CHD group, P < 0.01; 58 versus 51 ms in non-CHD group, P < or = 0.01). Other ventricular repolarization parameters also improved significantly in both MS groups following ET, but remained unchanged in the control group. A long-term ET program improves QTd in patients with MS with and without CHD.

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Cite This Study

Guiraud et al. (Fri,) conducted a observational in Metabolic Syndrome (n=54). Long-term exercise training vs. Non-exercising control group was evaluated on QT dispersion (QTd) (p=<0.01). Long-term exercise training significantly reduced QT dispersion from 66 to 56 ms in metabolic syndrome patients with coronary heart disease and from 58 to 51 ms in those without.

synapsesocial.com/papers/6a0fcb7bd12fb77703193c92 https://doi.org/https://doi.org/10.1536/ihj.51.41

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