Does small extracellular vesicle cargo modulate metabolic responsiveness to exercise training in insulin-resistant males?
Small extracellular vesicle cargo may contribute to modulating individual metabolic responsiveness to exercise training in insulin-resistant individuals.
max, mainly insulin-resistant (IR) persons (T2D and IR NDM) showed distinct alterations of circulating small extracellular vesicles (SEVs) along with lower inhibitory metabolic (protein kinase Cε activity) or inflammatory (nuclear factor κB) signaling in muscle of T2D or IR NDM, respectively. This is related to the specific alterations in SEV proteome reflecting down-regulation of the phospholipase C pathway (T2D) and up-regulated antioxidant capacity (IR NDM). Thus, SEV cargo may contribute to modulating the individual metabolic responsiveness to exercise training in humans.
Apostolopoulou et al. (Fri,) studied this question.
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