December 9, 2021Open Access

Association Between the Triglyceride–Glucose Index and the Incidence of Diabetes in People With Different Phenotypes of Obesity: A Retrospective Study

PICO estructurado

Does a higher Triglyceride-glucose (TyG) index predict the incidence of type 2 diabetes in people with different phenotypes of obesity?

Población

15,464 participants from the NAGALA cohort (Japan) without baseline diabetes, viral hepatitis, alcoholic fatty liver disease, or baseline medication usage, mean age 43.7 years, 45.5% female.

Intervención

Triglyceride-glucose (TyG) index evaluated as a continuous variable and across 8 different obesity phenotypes (based on BMI, visceral fat, and ectopic fat).

Resultado

Incident type 2 diabetes mellitus (defined as HbA1c ≥6.5%, fasting plasma glucose ≥7 mmol/L, or self-reported) at an average 5.38 years follow-up.

The TyG index is a significant independent predictor of incident type 2 diabetes, particularly in individuals with normal BMI but visceral or ectopic fat accumulation.

Resumen

Aim We aimed to examine the relationship between the Triglyceride–glucose (TyG) index and the incidence of type 2 diabetes in people with different phenotypes of obesity. Methods From May 1, 1994 to December 31, 2016, 15,464 participants were enrolled in the medical examination program at the Murakami Memorial Hospital to determine the relationship between the TyG index and the incidence of type 2 diabetes in people with different phenotypes of obesity after 5.38 years of follow-up. Results Besides triglycerides, HbA1c%, and FPG, the incidence of type 2 diabetes was found to be significantly associated with the TyG index (p 0.001), age (p 0.001), BMI (p = 0.033), current smoker (p 0.001), and fatty liver (p 0.001). In participants with visceral fat obesity and/or ectopic fat obesity and normal BMI, the TyG index was significantly associated with the incidence of type 2 diabetes after adjusting for confounding factors. In patients with BMI ≥25 mg/m 2 , although there was a trend of the relationship between the TyG index and the incidence of type 2 diabetes, the relationship was no longer positive. Conclusion In participants with obesity involving visceral fat obesity and/or fatty liver and normal BMI which is not a measure of body fat distribution, there was a significant association between the TyG index and incidence of T2DM.

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