Myocardial 3D T1 mapping using a variable flip angle approach with B1 correction yielded a mean myocardial T1 value of 1341 ± 42 ms in human volunteers.
Observational (n=7)
A variable flip angle approach for 3D myocardial T1 mapping at 3T provides reproducible and consistent T1 values, offering a potential tool for evaluating myocardial fibrosis.
PURPOSE: Myocardial T1 mapping is an emerging technique that could improve cardiovascular magnetic resonance diagnostic accuracy. In this study, a variable flip angle approach with B1 correction is proposed at 3T on the myocardium, employing standard 3D spoiled fast gradient echo and echo planar imaging sequences. METHODS: The method was tested on phantoms to determine the set of standard 3D spoiled fast gradient echo angles adapted to myocardial T1 measurements and was compared to the inversion-recovery spin-echo reference T1 method. Seven volunteers underwent magnetic imaging resonance to acquire myocardial T1 maps and T1 values of the human heart. RESULTS: This original method demonstrated good reproducibility in phantoms and a significant correlation between variable flip angle T1 values and reference inversion-recovery spin-echo T1 values. It yielded myocardial T1 values consistent with expected T1 and an increasing homogenization of myocardial segments owing to B1 correction. The mean myocardial T1 value was 1341 ± 42 ms. CONCLUSION: Myocardial 3D T1 mapping using the variable flip angle approach can potentially be useful for evaluating fibrosis on the entire myocardium using a standard clinical sequence.
Clique et al. (Mon,) conducted a observational in Myocardial T1 mapping (n=7). Variable flip angle approach with B1 correction at 3T vs. Inversion-recovery spin-echo reference T1 method was evaluated on Myocardial T1 values. Myocardial 3D T1 mapping using a variable flip angle approach with B1 correction yielded a mean myocardial T1 value of 1341 ± 42 ms in human volunteers.