Tin-Free Radical Cyclization Reactions Using the Persistent Radical Effect

Environmentally benign tin-free radical cyclization reactions allow the preparation of cyclic alcohol derivatives. The isomerizations are very easy to conduct and proceed in high yields for alkoxyamines with weak C−O bonds Eq. (1); R=Ph, functionalized aryl, heteroaryl, ester, or nitrile group. As a first application of the new method, the preparation of a complex tetracycle is presented.