Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 1991American Journal of Psychiatry

Bupropion did not cause significant conduction complications or exacerbate ventricular arrhythmias, but caused a rise in supine blood pressure and led to treatment discontinuation in 14% of patients due to adverse effects.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does bupropion cause adverse cardiovascular effects in depressed patients with preexisting heart disease?

Population

36 inpatients with DSM-III major depression and preexisting heart disease, including left ventricular…

Design

Cohort

Follow-up

3 weeks

Authors

SRSteven P. RooseGDGregory W. DalackAGAlexander H. Glassman

Discussion

Loading...

Member takes

Overview

Supports cautious bupropion use with BP monitoring in cardiac patients; leaves open need for RCTs on long-term safety.

Structured PICO

Does bupropion cause adverse cardiovascular effects in depressed patients with preexisting heart disease?

P
Population
36 inpatients with DSM-III major depression and preexisting heart disease, including left ventricular impairment (N = 15), ventricular arrhythmias (N = 15), and/or conduction disease (N = 21).
I
Intervention
Bupropion (mean +/- SD dose = 442 +/- 47 mg/day) for 3 weeks, added to continued baseline cardiac drug regimens.
O
Outcome
Cardiovascular functioning measured by pulse, blood pressure, high-speed ECG, 24-hour portable ECG, and radionuclide angiography.safety

Bupropion appears relatively safe regarding arrhythmias and conduction in depressed patients with heart disease, though it requires monitoring for increased blood pressure.

Limitations

  • Short duration of treatment
  • Small sample size

Cite This Study

Roose et al. (1991) studied this question.

synapsesocial.com/papers/6a109aa33564691d5cfe1dafhttps://doi.org/10.1176/ajp.148.4.512
View Full Paper
Ask AI
Bookmark
Share