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August 4, 1972

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Tumor Immunity in vitro: Destruction of a Mouse Ascites Tumor through a Cycling Pathway

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Resumen

Lymphocytes in peritoneal exudate from BALB/(c) mice immunized against ascites leukemia EL4 are uniquely efficient at destroying (51)chromiumlabeled EL4 cells in vitro. The lytic process depends upon the number of lymphocyte-tumor cell interactions. Efector lymphocytes are not inactivated as a result of lethal contact but can interact repeatedly with tumor cells.

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Tumor Immunity in vitro: Destruction of a Mouse Ascites Tumor through a Cycling Pathway | Synapse

Cite This Study

Berke et al. (Fri,) studied this question.

synapsesocial.com/papers/6a10ea8e975881a5546459ec https://doi.org/https://doi.org/10.1126/science.177.4047.433

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1REJECTION OF ASCITES TUMOR ALLOGRAFTS1972 · 143 citations
2CELLULAR IMMUNOABSORBENTS IN TRANSPLANTATION IMMUNITY1972 · 84 citations
3Cr LEAKAGE FROM AND UPTAKE OF TRYPAN BLUE BY TARGET CELLS UNDERGOING CELL-MEDIATED DESTRUCTION1972 · 19 citations
4Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.1968 · 1,373 citations
5Graft reaction in tissue culture. II. Quantification of the lytic action on mouse fibroblasts by rat lymphocytes sensitized on mouse embryo monolayers.1969 · 94 citations