A higher Systemic Immune-Inflammatory Index independently predicted persistent left ventricular systolic dysfunction in patients with peripartum cardiomyopathy (OR 1.177).
Cohort (n=61)
No
Does the systemic immune-inflammation index (SII) predict persistent LV systolic dysfunction in patients with peripartum cardiomyopathy?
The systemic immune-inflammation index (SII) is an independent predictor of persistent LV systolic dysfunction in patients with peripartum cardiomyopathy and may help identify high-risk patients.
Estimación del efecto: OR 1.177 (95% CI 1.038-1.335)
Tasa de eventos absoluta: 48% vs 16.7%
valor p: p=0.011
Background Peripartum cardiomyopathy (PPCM) is a potentially life-threatening complication of pregnancy. The identification of early prognostic markers in patients diagnosed with PPCM is very important. The systemic immune-inflammation index (SII) is a new inflammatory biomarker, and the aim of this study was to evaluate the prognostic value of SII in patients with PPCM. Methods A total of 61 patients with PPCM who were admitted in our hospital from 2015 to 2020 were retrospectively analyzed in this study. The follow-up period of all patients was at least 6 months after diagnosis. Recovery of left ventricular (LV) systolic function was defined as the presence of left ventricular ejection fraction 45%. The second endpoint was defined as composite adverse cardiac events, including cardiac death or hospitalization due to worsening heart failure. Univariate and multivariate logistic regression analysis were used to determine the independent predictors of non-recovery of LV systolic function. The receiver operating characteristic (ROC) curve analysis was used to establish a cut-off level of SII value to predict persistent LV systolic dysfunction. Results The follow-up duration was 40.5 ± 16.3 months. Among the 61 patients, 43 patients showed left ventricular recovery and 18 patients did not at the last follow-up visit. The baseline SII levels were significantly higher in the non-recovery group ( P 0.05). Multivariate logistic regression showed that the SII and left ventricular end-diastolic dimension (LVEDD) were independent predictors of persistent LV systolic dysfunction (OR: 1.177, 95% CI: 1.038–1.335, P = 0.011 and OR: 1.148, 95% CI: 1.011–1.304, P = 0.033, respectively). A SII value of 876 was the best cut-off value (the area under the curve was 0.791, 95% CI: 0.667–0.915, P 0.05), and the sensitivity and specificity were 73 and 71%, respectively. Conclusions The SII and LVEDD are independent prognostic factors for persistent LV systolic dysfunction in patients with PPCM. The SII may be a useful tool for identifying high-risk PPCM patients.
Zhang et al. (Thu,) conducted a cohort in Peripartum Cardiomyopathy (n=61). High Systemic Immune-Inflammatory Index (SII > 876) vs. Low Systemic Immune-Inflammatory Index (SII < 876) was evaluated on Persistent left ventricular systolic dysfunction (LVEF ≤ 45%) (OR 1.177, 95% CI 1.038-1.335, p=0.011). A higher Systemic Immune-Inflammatory Index independently predicted persistent left ventricular systolic dysfunction in patients with peripartum cardiomyopathy (OR 1.177).