What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Burnout (n=73). Intervention: Burnout vs. Healthy controls. Primary outcome: HOMA-IR (insulin resistance) (p=0.592).

What does this research mean for the field?

Burnout cases overall do not differ significantly from healthy controls in insulin resistance or glucose levels during an oral glucose tolerance test, although individuals with severe burnout or depressive symptoms exhibit elevated levels indicating increased diabetic risk. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 17, 2024Stress5 citationsOpen Access

Study of glucose homeostasis in burnout cases using an oral glucose tolerance test

ALAnna-Karin LennartssonNational Academy of Medicine IJIngibjörg H. JónsdóttirNational Academy of Medicine PJPer‐Anders JanssonNational Academy of Medicine

Resultado clave

Burnout cases overall did not differ significantly from healthy controls in insulin resistance (HOMA-IR 1.40 vs 1.57) or glucose levels during an oral glucose tolerance test.

Diseño del estudio

Tipo

Cross-Sectional (n=73)

Multicéntrico

PICO estructurado

Do individuals with stress-related burnout exhibit altered glucose and insulin levels during an oral glucose tolerance test compared to healthy controls?

Población

73 adults aged 24-55, comprising 38 cases with stress-related burnout (13 men, 25 women) and 35 healthy controls (13 men, 22 women).

Intervención

Oral glucose tolerance test (OGTT)

Comparador

Healthy controls

Resultado

Glucose and insulin levels in response to a standard oral glucose tolerance testsurrogate

Severe burnout and depressive symptoms are associated with higher glucose and insulin levels during an OGTT, indicating a potential increased risk for type 2 diabetes.

Resultado numérico

Tasa de eventos absoluta: 1.4% vs 1.57%

valor p: p=0.592

Limitaciones

Small sample size restricted controlling for background factors
Cross-sectional design does not allow investigation of causal links
Only self-reports used, burnout case population not clinically assessed for diagnoses

Resumen

Burnout is caused by long term psychosocial stress and has, besides the fatigue and mental health burden, been associated with increased risk of adverse physical health, such as for example type 2 diabetes. This study aims to investigate the glucose and insulin levels in individuals with stress related burnout, by assessing these metabolic markers in response to a standard oral glucose tolerance test (OGTT). 38 cases with burnout (13 men and 25 women) and 35 healthy controls (13 men and 22 women) in the age 24-55 were included in the study. The burnout group overall did not differ from healthy controls in glucose or insulin levels during the OGTT. However, the burnout cases who reported more severe burnout symptoms exhibited significantly higher levels of both glucose and insulin levels during the OGTT compared to burnout cases reporting lower severity of symptoms. Furthermore, the group of burnout cases who reported symptoms of depression exhibited higher insulin levels during OGTT compared to the burnout cases without depressive symptoms. The observed higher levels in the burnout cases with most severe symptoms indicate an increased diabetic risk in these patients and it may be of importance to follow glucose and insulin levels in individuals with more severe symptoms of burnout i.e. to perform an OGTT.

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